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It is the southern terminus of the West Coast Main Line to Liverpool Lime Street, Manchester Piccadilly, Edinburgh Waverley and Glasgow Central.

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Hlavní větev mezi nádražími London Euston a Glasgow Central měří 645 km s hlavními nácestnými stanicemi Milton Keynes, Rugby, Nuneaton, Tamworth, Stafford, Crewe, Warrington, Preston, Lancaster, a Carlisle.

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